糖皮质激素受体在动物应激时的作用及其调控

Journal of Tianjin Agricultural University ›› 2016, Vol. 23 ›› Issue (1): 57-61.

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Function and Regulation of Glucocorticoid Receptor in Animal Stress

WEI Shi^{1, 2}

1. Guangdong Wens Foodstuff Group CO., LTD, Rencun Branch Company, Xinxing 527400, Guangdong Province, China;
2. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

Received:2015-10-28 Online:2016-03-20 Published:2019-10-14

Abstract

Abstract: Stress reaction is an adaptive response of all living organism to stressful events, and it has important significance for their survival. The main feature of stress reaction is activation of the hypothalamus- pituitary- adrenal axis (HPA axis). Abundant glucocorticoid receptor expressed in the hippocampus, amygdala and hypothalamus. Glucocorticoid receptor plays a crucial role in regulating the HPA axis' activity. The function of GR can be regulated by MR, 11βHSDs and GR's polymorphism.

Key words: stress, hypothalamus-pituitary-adrenal axis, glucocorticoid receptor, regulation

CLC Number:

S852.21

WEI Shi. Function and Regulation of Glucocorticoid Receptor in Animal Stress[J]. Journal of Tianjin Agricultural University, 2016, 23(1): 57-61.

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Function and Regulation of Glucocorticoid Receptor in Animal Stress

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