Abstract: The long-term toxicity of clear away lung-heat to relieve asthma oral liquid in SD rats was researched by continuous perfusion in order to expose its clinical innocuity. 120 SD rats (males and females) were randomly divvied into control group and clear away lung-heat to relieve asthma oral liquid in 3 different dosage groups (2.52 g/kg, 5.04 g/kg and 10.08 g/kg, 30 in each group). The SD rats were administered with clear away lung-heat to relieve asthma oral liquid by continuous perfusion for 90 days. The body weight, food intake, hematology, blood biochemistry and organ coefficient were measured for the overall toxicity assessment to rats. Results: After 90 days, no death occurred in 120 rats. The appetite and excretion of clear away lung-heat to relieve asthma oral liquid rats were normal and their feathers were sleek. During the administration period, the weight, food intake, hematology, blood biochemistry and organ coefficientof the test group rats had no significant differencefrom the control group(P>0.05). It was concluded that with the dose of 2.52 g/kg, 5.04 g/kg and 10.08 g/kg clear away lung-heat to relieve asthma oral liquid continuous perfusing, there is no harmful effect for SD rats.

Key words: clear away lung-heat to relieve asthma oral liquid, rat, long-term toxicity