副猪嗜血杆菌免疫机制研究进展

doi:10.19640/j.cnki.jtau.2018.02.017

Journal of Tianjin Agricultural University ›› 2018, Vol. 25 ›› Issue (2): 70-73.doi: 10.19640/j.cnki.jtau.2018.02.017

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Research advance on immune mechanism of Haemophilus parasuis

LIU Yan-fei, YANG Jian-de^{Corresponding Author}

College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China

Received:2018-01-30 Online:2018-06-20 Published:2019-11-12

Abstract

Abstract: Haemophilus parasuis is a gram negative bacterium commonly found in the upper respiratory tract and is the etiological agent of Glasser’s disease, a systemic inflammatory infection characterized by polyserositis, arthritis and meningitis. Recent studies on innate immunity to H. parasuis have demonstrated that porcine alveolar macrophages (PAMs) are able to differentially up-regulate several genes related to inflammation and phagocytosis, and several pro-inflammatory cytokines are produced by porcine cells upon exposure to H. parasuis. The susceptibility of H. parasuis strains to phagocytosis by PAMs and the bactericidal effect of complement are influenced by the virulent phenotype of the strains. However, in the presence of specific antibodies against H. parasuis, virulent strains become susceptible to phagocytosis. Antimicrobials are commonly used in the swine industry to help treat and control Glasser’s disease. Some of the common antimicrobials have been shown to reduce colonization by H. parasuis, thus the paper reviews the research on innate and adaptive immune responses to H. parasuis and discusses the potential effect of enrofloxacin on the development of a protective immune response against H. parasuis infection.

Key words: Haemophilus parasuis, innate immunity, adaptive immunity, mechanism, enrofloxacin

CLC Number:

S852.61

LIU Yan-fei, YANG Jian-de. Research advance on immune mechanism of Haemophilus parasuis[J]. Journal of Tianjin Agricultural University, 2018, 25(2): 70-73.

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Research advance on immune mechanism of Haemophilus parasuis

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