Profilin1的生物学作用研究进展

doi:10.19640/j.cnki.jtau.2022.03.014

Journal of Tianjin Agricultural University ›› 2022, Vol. 29 ›› Issue (3): 78-83.doi: 10.19640/j.cnki.jtau.2022.03.014

• Reviews • Previous Articles Next Articles

Research progress on the biological function of Profilin1

Zi Jingjing, Yang Xu, Lai Yuting, Li Xin, Ding Xiangbin, Zhang Linlin^{Corresponding Author}

Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China

Received:2020-07-28 Online:2022-09-30 Published:2022-10-10

Abstract

Abstract: Profilin which was first discovered in 1976 was one of the earliest actin binding proteins, and has been widely studied because of its important biological role. Profilin1 is the most ubiquitous subtype because it can bind actin to regulate the polymerization of the cytoskeleton. Many recent studies have shown that Profilin1 also plays an important role in cancer and human diseases. This review mainly introduced the biological role of Profilin1, further explained its regulatory mechanism on the cytoskeleton, and discussed on the physiological and pathological role of Profilin1 in cancer and human diseases.

Key words: Profilin1, cytoskeleton, actin, cancer, disease

CLC Number:

Zi Jingjing, Yang Xu, Lai Yuting, Li Xin, Ding Xiangbin, Zhang Linlin. Research progress on the biological function of Profilin1[J]. Journal of Tianjin Agricultural University, 2022, 29(3): 78-83.

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://xuebao.tjau.edu.cn/EN/10.19640/j.cnki.jtau.2022.03.014

http://xuebao.tjau.edu.cn/EN/Y2022/V29/I3/78

References

[1] WITKE W,SUTHERLAND J D,SHARPE A,et al.Profilin I is essential for cell survival and cell division in early mouse development[J]. Proc Natl Acad Sci U S A,2001,98(7):3832-3836.
[2] BIRBACH A.Profilin,a multi-modal regulator of neuronal plasticity[J]. Bioessays,2008,30(10):994-1002.
[3] CARLSSON L,NYSTROM L E,SUNDKVIST I,et al.Actin polymerizability is influenced by profilin,a low molecular weight protein in non-muscle cells[J]. J Mol Biol,1977,115(3):465-483.
[4] WITTENMAYER N,JANDRIG B,ROTHKEGEL M,et al.Tumor suppressor activity of profilin requires a functional actin binding site[J]. Mol Biol Cell,2004,15(4):1600-1608.
[5] METZLER W J,FARMER B N,CONSTANTINE K L,et al.Refined solution structure of human profilin I[J]. Protein Sci,1995,4(3):450-459.
[6] REINHARD M,GIEHL K,ABEL K,et al.The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins[J]. EMBO J,1995,14(8):1583-1589.
[7] BARZIK M,KOTOVA T I,HIGGS H N,et al.Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins[J]. J Biol Chem,2005,280(31):28653-28662.
[8] WITKE W.The role of profilin complexes in cell motility and other cellular processes[J]. Trends Cell Biol,2004,14(8):461-469.
[9] HENDERSON C A,GOMEZ C G,NOVAK S M,et al.Overview of the muscle cytoskeleton[J]. Compr Physiol,2017,7(3):891-944.
[10] YARMOLA E G,BUBB M R.How depolymerization can promote polymerization:The case of actin and profilin[J]. Bioessays,2009,31(11):1150-1160.
[11] KOVAR D R,HARRIS E S,MAHAFFY R,et al.Control of the assembly of ATP-and ADP-actin by formins and profilin[J]. Cell,2006,124(2):423-435.
[12] MAHONEY N M,JANMEY P A,ALMO S C.Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation[J]. Nat Struct Biol,1997,4(11):953-960.
[13] YANG C,HUANG M,DEBIASIO J,et al.Profilin enhances Cdc42-induced nucleation of actin polymerization[J]. J Cell Biol,2000,150(5):1001-1012.
[14] ROTTY J D,WU C,HAYNES E M,et al.Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways[J]. Dev Cell,2015,32(1):54-67.
[15] SUAREZ C,CARROLL R T,BURKE T A,et al.Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex[J]. Dev Cell,2015,32(1):43-53.
[16] DA S J,DOTTI C G.Breaking the neuronal sphere:Regulation of the actin cytoskeleton in neuritogenesis[J]. Nat Rev Neurosci,2002,3(9):694-704.
[17] LAMBRECHTS A,JONCKHEERE V,PELEMAN C,et al.Profilin- I-ligand interactions influence various aspects of neuronal differentiation[J]. J Cell Sci,2006,119(8):1570-1578.
[18] DING Z,BAE Y H,ROY P.Molecular insights on conte- xtspecific role of profilin-1 in cell migration[J]. Cell Adh Migr,2012,6(5):442-449.
[19] YAO W,JI S,QIN Y,et al.Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1alpha axis[J]. Mol Cancer,2014,13:187.
[20] ZOU L,DING Z,ROY P.Profilin-1 overexpression inhibits proliferation of MDA-MB-231 breast cancer cells partly through p27kip1 upregulation[J]. J Cell Physiol,2010,223(3):623-629.
[21] WU N,ZHANG W,YANG Y,et al.Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migration[J]. Proteomics,2006,6(22):6095-6106.
[22] SHEN K,XI Z,XIE J,et al.Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1[J]. Oncotarget, 2016,7(35):56650-56663.
[23] WANG Z,SHI Z,ZHANG L,et al.Profilin 1,negatively regulated by microRNA-19a-3p,serves as a tumor suppressor in human hepatocellular carcinoma[J]. Pathol Res Pract,2019,215(3):499-505.
[24] JANKE J,SCHLUTER K,JANDRIG B,et al.Suppression of tumorigenicity in breast cancer cells by the microfilament protein profilin 1[J]. J Exp Med,2000,191(10):1675-1686.
[25] ZOU L,JARAMILLO M,WHALEY D,et al.Profilin-1 is a negative regulator of mammary carcinoma aggressiveness[J]. Br J Cancer,2007,97(10):1361-1371.
[26] DING Z,LAMBRECHTS A,PAREPALLY M,et al.Silencing profilin-1 inhibits endothelial cell proliferation, migration and cord morphogenesis[J]. J Cell Sci,2006,119(19):4127-4137.
[27] FAN Y,ARIF A,GONG Y,et al.Stimulus-dependent phosphorylation of profilin-1 in angiogenesis[J]. Nat Cell Biol,2012,14(10):1046-1056.
[28] DAS T,BAE Y H,WELLS A,et al.Profilin-1 overexpression upregulates PTEN and suppresses AKT activation in breast cancer cells[J]. J Cell Physiol,2009,218(2):436-443.
[29] KANAUJIYA J K,LOCHAB S,KAPOOR I,et al.Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF₇ breast cancer cells[J]. Proteomics,2013,13(14):2100-2112.
[30] MINAMIDA S,IWAMURA M,KODERA Y,et al.Profilin 1 overexpression in renal cell carcinoma[J]. Int J Urol,2011,18(1):63-71.
[31] WANG Y,ZHANG J,GAO H,et al.Profilin-1 promotes the development of hypertension-induced artery remodeling[J]. J Histochem Cytochem,2014,62(4):298-310.
[32] MOUSTAFA-BAYOUMI M,ALHAJ M A,EL-SAYED O,et al.Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1[J]. J Biol Chem,2007,282(52):37632-37639.
[33] HASSONA M D,ABOUELNAGA Z A,ELNAKISH M T,et al.Vascular hypertrophy-associated hypertension of profilin1 transgenic mouse model leads to functional remodeling of peripheral arteries[J]. Am J Physiol Heart Circ Physiol,2010,298(6):H2112-H2120.
[34] 牛欢欢,钟久昌. 前纤维蛋白1与心血管疾病关系研究的进展[J]. 心血管康复医学杂志,2010,19(2):220-223.
[35] WOODWARD M.Use of national data sources in diabetes epidemiology[J]. Lancet Diabetes Endocrinol,2015,3(2):92-93.
[36] HAMILTON S J,WATTS G F.Endothelial dysfunction in diabetes:Pathogenesis,significance,and treatment[J]. Rev Diabet Stud,2013,10(2):133-156.
[37] PITOCCO D,ZACCARDI F,DI S E,et al.Oxidative stress,nitric oxide,and diabetes[J]. Rev Diabet Stud,2010,7(1):15-25.
[38] ZHAO D,YANG J,YANG L.Insights for oxidative stress and mTOR signaling in myocardial ischemia/reperfusion injury under diabetes[J]. Oxid Med Cell Longev,2017,2017:6437467.
[39] NAWROCKA D,KORNICKA K,SZYDLARSKA J,et al.Basic fibroblast growth factor inhibits apoptosis and promotes proliferation of adipose-derived mesenchymal stromal cells isolated from patients with type 2 diabetes by reducing cellular oxidative stress[J]. Oxid Med Cell Longev,2017,2017:3027109.
[40] ROMEO G,FRANGIONI J V,KAZLAUSKAS A.Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction[J]. FASEB J,2004,18(6):725-727.
[41] ROMEO G R,MOULTON K S,KAZLAUSKAS A.Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse[J]. Circ Res,2007,101(4):357-367.
[42] LI Z,ZHONG Q,YANG T,et al.The role of profilin-1 in endothelial cell injury induced by advanced glycation end products(AGEs)[J]. Cardiovasc Diabetol,2013,12:141.
[43] SREEDHARAN J,BROWN R J.Amyotrophic lateral sclerosis:Problems and prospects[J]. Ann Neurol,2013,74(3):309-316.
[44] 卢义晨. 前纤维蛋白1在多发性骨髓瘤中通过促进自噬参与细胞耐药的研究[D]. 长春:吉林大学,2018.
[45] RENTON A E,CHIO A,TRAYNOR B J.State of play in amyotrophic lateral sclerosis genetics[J]. Nat Neurosci,2014,17(1):17-23.
[46] IIDA A,HOSONO N,SANO M,et al.Novel deletion mutations of OPTN in amyotrophic lateral sclerosis in Japanese[J]. Neurobiol Aging,2012,33(8):1819-1843.
[47] SMITH B N,TICOZZI N,FALLINI C,et al.Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS[J]. Neuron,2014,84(2):324-331.
[48] SMITH B N,VANCE C,SCOTTER E L,et al.Novel mutations support a role for Profilin 1 in the pathogenesis of ALS[J]. Neurobiol Aging,2015,36(3):1602-1617.
[49] INGRE C,LANDERS J E,RIZIK N,et al.A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US,Nordic,and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts[J]. Neurobiol Aging,2013,34(6):1701-1708.
[50] WU C H,FALLINI C,TICOZZI N,et al.Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis[J]. Nature,2012,488(7412):499-503.
[51] ALKAM D,FELDMAN E Z,SINGH A,et al.Profilin1 biology and its mutation,actin(g)in disease[J]. Cell Mol Life Sci,2017,74(6):967-981.
[52] FREISCHMIDT A,SCHOPFLIN M,FEILER M S,et al.Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton[J]. BMC Neurosci,2015,16:77.
[53] DEL P E,BEMPORAD F,TATINI F,et al.Mutations of profilin-1 associated with amyotrophic lateral sclerosis promote aggregation due to structural changes of its native state[J]. ACS Chem Biol,2015,10(11):2553-2563.
[54] DEL P E,GORI L,CHITI F.Biophysical analysis of three novel profilin-1 variants associated with amyotrophic lateral sclerosis indicates a correlation between their aggregation propensity and the structural features of their globular state[J]. Biol Chem,2016,397(9):927-937.

Research progress on the biological function of Profilin1

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	An Ruiyu, Hao Zhibin. Regional segmentation method for wheat leaf diseases and insect pests based on semi-supervised active learning [J]. Journal of Tianjin Agricultural University, 2024, 31(2): 87-93.
[2]	Su Dan, Deng Yongzhuo. Research progress and problems in crop disease image recognition [J]. Journal of Tianjin Agricultural University, 2023, 30(3): 75-79.
[3]	Ding Qiaoling, Qin Shunyi, Li Liuan, Li Jianjun. Exploration on the integration of “Curriculum Ideological and Political” elements into the teaching of Small Animal Infectious Diseases [J]. Journal of Tianjin Agricultural University, 2023, 30(1): 105-108.
[4]	LUO Fu-li, NIU Yu-chen, HU Xiu-cai, LÜ Ai-jun, YE Ming-hao, SUN Jing-feng. Clinical signs and histochemical observation of Citrobacter freundii disease in turtle（Trachemys scripta elegans） [J]. Journal of Tianjin Agricultural University, 2020, 27(2): 44-47.
[5]	LU Tong, YANG Xiu-rong, HUO Jian-fei, SUN Shu-qin, LIU Chun-yan, HAO Yong-juan. Prevention and cure of rice seeding disease in Tianjin [J]. Journal of Tianjin Agricultural University, 2019, 26(2): 46-50.
[6]	CHAI Ying-hui, FAN Xin-hao, LIU Sheng-nan, GAO Jin-wei, JIA Xu-ying, SHAO Peng, ZHOU Wen-li. Research progress on the formation and influencing factors of intestinal microorganisms of sea cucumber [J]. Journal of Tianjin Agricultural University, 2019, 26(2): 84-88.
[7]	LI Xin, MENG Jia-li, SHANG Cui-ling, LI Dan, LAN Zhao-yu, WANG Xiao-yue, JIN Tian-ming. Epidemiological investigation of canine dermatosis in a pet clinic in Tianjin [J]. Journal of Tianjin Agricultural University, 2019, 26(1): 50-53.
[8]	WANG Yu-hui, LI Xin, SUN Xiao-li, MENG Jia-li, SHANG Cui-ling, LIN Jing, JIN Tian-ming. The isolation and identification of pathogen and drug susceptibility test for Actinobacillus pleuropneumoniae [J]. Journal of Tianjin Agricultural University, 2018, 25(4): 33-37.
[9]	ZAN Fang, BAI Hai-xia, CUI Jun. Investigation and Prevention Control Measures of Common Infectious Diseases in Canine in Tianjin Area [J]. Journal of Tianjin Agricultural University, 2017, 24(4): 90-93.
[10]	JI Si-qi, WU Fang, LI Nai-xiang. Static Early-warning Model of Vegetable DiseasesBased on Decision Tree [J]. Journal of Tianjin Agricultural University, 2017, 24(2): 77-80.
[11]	DU Qing-bing, GONG Jian-fang, ZHANG Dong-chao, LI Xiao-hui, GAO Ke-ke, LIN Jing, JIN Tian-ming. Diagnostic Analysis of Piglet Edema Disease from a Large Scale Pig Farm in Tianjin [J]. Journal of Tianjin Agricultural University, 2016, 23(3): 55-56.
[12]	ZHANG Wei, REN Chao, WANG Yi-min, HU Ye, CUI Jun, SUN Yue, ZHUGE Zeng-yu, JIN Tian-ming. Analysis of Occurrence and Epidemic Causes of Zoonosis [J]. Journal of Tianjin Agricultural University, 2016, 23(2): 60-62.
[13]	WANG Dong-yuan, WANG Yu-shun, GU Yu, JIN Tian-ming, GAO Feng. Analysis and Study on Cow Hoof Disease in Tianjin Area [J]. Journal of Tianjin Agricultural University, 2015, 22(2): 37-39.
[14]	HU Xuan, SUN Jing-feng, CHEN Cheng-xun, XING Ke-zhi. Isolation and Identification of Pathogen of Ascites Disease from Cynoglossus semilaevis Günther and Its Antibiotic Sensitivity Analysis [J]. Journal of Tianjin Agricultural University, 2014, 21(3): 12-16.
[15]	GAO Jing, DONG Dong-xiao, LONG Yu-qing, LI Meng, LI Liu-an, JIN Tian-ming. Antitumor Mechanism of Newcastle Disease Virus HN Protein and Its Research Progress [J]. Journal of Tianjin Agricultural University, 2014, 21(3): 49-52.