苦杏仁提取物乳剂的处方研究

doi:10.19640/j.cnki.jtau.2018.04.013

Journal of Tianjin Agricultural University ›› 2018, Vol. 25 ›› Issue (4): 58-62.doi: 10.19640/j.cnki.jtau.2018.04.013

• Researches and Scientific Notes • Previous Articles Next Articles

Emulsion formulation optimization of extracts from Armeniacae Semen

CHEN Kun^a, QI Jin-yu^a, LIU Li-yao^{a,b,Corresponding Author}, WANG Qing-kui^b

Tianjin Agricultural University, a. College of Basic Science, b. Tianjin Key Lab of Aquatic Ecology and Aquaculture, Tianjin 300384, China

Received:2018-05-09 Online:2018-12-20 Published:2019-11-12

Abstract

Abstract: Amygdalin is abundant in effective extracts from Armeniacae Semen with bioactivities of relieving cough and asthma through oral administration in lower dose. Combining advantages of emulsion in drug delivery, homogeneous and stable water-in-oil type emulsion was established successfully after relevant formulation optimization. In this study, effective extracts were acquired through ultrasonic extraction firstly. Afterwards, comprehensive scoring of homogeneity, centrifugal stability and cold/heat resistance were set as the evaluation indicators in orthogonal screening. And optimal proportion of oil phase, emulsifier and stabilizer were obtained for the preparation of Armeniacae Semen extracts emulsion. In the optimal formulation, medium-chain triacylglycerol was used as the oil phase and soybean lecithin was chosen as emulsifier with the mass percentage of 30% and 1.5% respectively. Moreover, tragacanth was added as stabilizer with addition amount of 1.2%. Under the optimal formulation, 3 batches of Armeniacae Semen extracts emulsion were prepared with favorable stability and homogeneity. This study provides the basis for further application of Armeniacae Semen extracts emulsion.

Key words: Armeniacae Semen extracts, orthogonal screening, emulsion, formulation screening

CLC Number:

CHEN Kun, QI Jin-yu, LIU Li-yao, WANG Qing-kui. Emulsion formulation optimization of extracts from Armeniacae Semen[J]. Journal of Tianjin Agricultural University, 2018, 25(4): 58-62.

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Emulsion formulation optimization of extracts from Armeniacae Semen

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