烟酰胺乳膏剂的制备处方研究

doi:10.19640/j.cnki.jtau.2020.01.017

Journal of Tianjin Agricultural University ›› 2020, Vol. 27 ›› Issue (1): 76-81.doi: 10.19640/j.cnki.jtau.2020.01.017

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Study on ointment formulation design of nicotinamide

HONG Jing^a, LIU Li-yao^{a,b,Corresponding Author}, WANG Qing-kui^b

Tianjin Agricultural University a. College of Basic Science, b. Tianjin Key Lab of Aquatic Ecology and Aquaculture, Tianjin 300384, China

Received:2019-04-22 Published:2020-04-01

Abstract

Abstract: Nicotinamide is a kind of pyridine derivative, which has various pharmacological effects such as inhibition of melanic transmission, anti-free radical, anti-aging, anti-inflammatory and enhancement of skin barrier after transdermal administration. However, due to its structure of amide, nicotinamide could be oxidized to nicotinic acid, which could cause dermal irritation and side effects. Thus, water-in-oil（W/O）ointment was prepared to enhance stability and compliance of nicotinamide. In this investigation, comprehensive scoring of homogeneity, extensibility, centrifugal stability and cold/heat resistance was set as the evaluation indicator to obtain the optimal proportion of oil phase, emulsifier and coemulsifier through single-factor experiment and orthogonal screening. under the optimal formulation. Span-60 and Tween-80 were used as emulsifier and coemulsifier respectively with the mass percentage of 1%, and the weight ratio of oil to water was 6∶4. Under the selected formulation, storage stability of ointment remained in 3 months under 25 ℃, which provides the basis for practical application.

Key words: nicotinamide, ointment, single-factor experiment, orthogonal screening, formulation optimization

CLC Number:

HONG Jing, LIU Li-yao, WANG Qing-kui. Study on ointment formulation design of nicotinamide[J]. Journal of Tianjin Agricultural University, 2020, 27(1): 76-81.

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References

[1] 杨驰,郑咏秋,戴敏. 烟酰胺药理作用研究进展[J]. 临床肺科杂志,2011,16(12):1914-1916.
[2] 朱晨杰,付静雯,谭卓涛,等. 天然烟酰胺辅因子再生体系及其人工类似物研究进展[J]. 化工学报,2018,69(1):259-271.
[3] 李丽花,胡迎芬,李勇,等. 补充烟酰胺与硫胺素对肥胖大鼠体重和能量代谢的影响[J]. 营养学报,2014,36(5):466-470.
[4] Minocha R,Damian D L,Halliday G M.Melanoma and nonmelanoma skin cancer chemoprevention:A role for nicotinamide[J]. Photodermatol Photoimmunol Photomed,2018,34(1):5-12.
[5] 秦烨,张偌瑜,缪朝玉,等. 烟酰胺磷酸核糖转移酶抑制剂在肿瘤治疗方面的研究进展[J]. 第二军医大学学报,2012,33(7):794-798.
[6] 于志杰,林旭. 烟酸对神经系统的保护作用研究进展[J]. 营养健康新观察,2004(2):32-35.
[7] 成海建,臧坤,刘晓牧,等. 添加烟酰胺对小鼠脂肪细胞能量代谢的影响[J]. 云南农业大学学报,2013,28(6):791-795.
[8] Chen A C,Martin A J,Damian D L.Nicotinamide for skin cancer chemoprevention[J]. N Engl Med,2016,374(8):789-790.
[9] Chen A C,Martin A J,Dalziell R A,et al.A phase II randomized controlled trial of nicotinamide for skin cancer chemoprevention in renal transplant recipients[J]. Br J Dermatol,2016,175(5):1073-1075.
[10] Shipman L.Skin cancer:Nicotinamide chemoprevention trial success[J]. Nature Reviews Cancer,2015,15(12):697.
[11] 虞佳,罗美兰,林森,等. 4.5%烟酰胺凝胶的皮肤急性毒性与皮肤刺激性研究[J]. 南昌大学学报(医学版),2014,54(5):27-28.
[12] 崔晓鸽,曹伶俐,侯佳威,等. 白杨素磷脂复合物的制备及其药动学行为[J]. 中成药,2017,39(5): 934-939.
[13] 王可可,易丽昕,姜明燕. 星点设计效应面法优化盐酸文拉法辛油包水乳剂处方[J]. 医药导报,2015,34(5):644-648.
[14] 邓菲,吴丽君,周雪,等. 氨甲环酸乳膏剂的处方筛选[J]. 华西药学杂志,2018,33(1):28-30.
[15] 祁金玉,李娜坤,刘黎瑶,等. 紫苏叶提取物乳膏剂的处方研究[J]. 天津农学院学报,2018,25(3):69-73.
[16] 王红茜,凡苗振,邹琴,等. 黄芩总黄酮提取物软膏剂的处方工艺研究[J]. 天津农学院学报,2017,24(4):33-37.

Study on ointment formulation design of nicotinamide

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