盐酸小檗碱-磷脂复合物的处方工艺研究

doi:10.19640/j.cnki.jtau.2019.02.015

Journal of Tianjin Agricultural University ›› 2019, Vol. 26 ›› Issue (2): 64-68.doi: 10.19640/j.cnki.jtau.2019.02.015

• Researches and Scientific Notes • Previous Articles Next Articles

Formulation optimization and research on berberine hydrochloride phospholipid complex

WANG Qing^a, LIU Li-yao^a,b, WANG Qing-kui^b

Tianjin Agricultural University, a. Department of Biopharmaceuticals, College of Basic Science; b. Tianjin Key Lab of Aqua-Ecology and Aquaculture, Tianjin 300384, China

Received:2019-01-03 Online:2019-06-20 Published:2019-09-19

Abstract

Abstract: Berberine hydrochloride is effective medicine for gastrointestinal bacterial infection treatment clinically. However, as for its poor lipophilicity, oral bioavailability of beriberine hydrochloride is relatively low. This study was designed to increase the lipophilicity of berberine hydrochloride using phospholipid complexation technology. In this study, associative efficiency（AE） was set as screening parameter and optimal formulation of berberine hydrochloride phospholipid complex was obtained using solvent evaporation method based on single factor screening and orthogonal design. Under the selected formulation, AE of berberine hydrochloride phospholipid complex could reach 90% and storage stability remained in 6 months under 4 ℃, which provided the basis for practical application.

Key words: berberine hydrochloride, phospholipid complex, orthogonal screening, formulation optimization

CLC Number:

R944.9

WANG Qing, LIU Li-yao, WANG Qing-kui. Formulation optimization and research on berberine hydrochloride phospholipid complex[J]. Journal of Tianjin Agricultural University, 2019, 26(2): 64-68.

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://xuebao.tjau.edu.cn/EN/10.19640/j.cnki.jtau.2019.02.015

http://xuebao.tjau.edu.cn/EN/Y2019/V26/I2/64

References

[1] 李波,朱维良,陈凯先. 小檗碱及其衍生物的研究进展[J]. 药学学报,2008,43(8):773-787.
[2] 张磊,王京,聂晶,等. 小檗碱衍生物的活性研究进展[J].中国医药指南,2015(12):32-34.
[3] 钟慈平,骞宇,舒畅,等. 小檗碱及其衍生物抑菌作用研究进展[J]. 食品科学,2013,34(7):321-325.
[4] 王成艳,胡兴亚. 小檗碱及其衍生物抗白血病活性的研究进展[J]. 解剖学研究,2016(3):203-205.
[5] 金鑫,宋霞,曹永兵,等. 小檗碱的结构改造及其药理活性的研究进展[J]. 药学实践杂志,2017,32(3):171-175.
[6] 李楠,冯玲玲,蒋学华,等. 黄芩苷磷脂复合物大鼠在体胃肠道吸收研究[J]. 中国药学杂志,2016,51(12):994-998.
[7] 王梦姝,吕晓玲,赵焕焦,等. 黑米花色苷磷脂复合物的制备及生物利用度[J]. 食品科技,2017(5):242-245.
[8] 郑林. 磷脂复合物对中药制剂口服吸收的影响[J]. 中国抗生素杂志,2015,40(6):468-473.
[9] 左巨波,尚京川. 盐酸小檗碱磷脂复合物的制备和理化性质研究[J]. 中国新药杂志,200,18(14):1372-1376.
[10] 华玉铃,贺祝英,张建玲,等. 中药软膏剂制备方法的研究进展[J]. 贵阳中医学院学报,2008,30(2):66-69.
[11] 崔晓鸽,曹伶俐,侯佳威,等. 白杨素磷脂复合物的制备及其药动学行为[J]. 中成药,2017,39(5):934-939.
[12] 宋婷,宋丹,管海燕,等. 松萝酸磷脂复合物在大鼠体内的药动学及组织分布研究[J]. 中草药,2018,49(6):1358-1364.
[13] Shi C,Tong Q,Fang J,et al.Preparation, characterization and in vivo studies of amorphous solid dispersion of berberine with hydrogenated phosphatidylcholine[J]. European Journal of Pharmaceutical Sciences,2015,74:11-17.
[14] Cui F,Shi K,Zhang L Q,et al.Biodegradable nanoparticles loaded with insulin—phospholipid complex for oral delivery:Preparation,in vitro characterization and in vivo evaluation[J]. Journal of Controlled Release,2006,114(2):242-250.
[15] 余凤玮,聂绩,袁野. 穿心莲内酯磷脂复合物的制备及表征[J]. 中国药房,2016,27(10):1409-1411.

Formulation optimization and research on berberine hydrochloride phospholipid complex

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 10

Recommended Articles

Metrics

Comments

[1]	Chen Hanxing, Dai Wenjie, Liu Liyao, Wang Qingkui, Cong Fangdi. Optimization of extraction method for total flavonoids from pomelo peel [J]. Journal of Tianjin Agricultural University, 2023, 30(2): 49-53.
[2]	LIU Ze-wei, LIU Li-yao, WANG Qing-kui, LIU Lin, YE Yi-xian. Emulsion formulation optimization of berberine hydrochloride [J]. Journal of Tianjin Agricultural University, 2020, 27(3): 70-73.
[3]	KONG Yun, LIU Li-yao, XIONG Qian, WANG Qing-kui. Formulation optimization of cinnamaldehyde-hydroxypropyl-β-cyclodextrin inclusion complex [J]. Journal of Tianjin Agricultural University, 2020, 27(1): 70-75.
[4]	HONG Jing, LIU Li-yao, WANG Qing-kui. Study on ointment formulation design of nicotinamide [J]. Journal of Tianjin Agricultural University, 2020, 27(1): 76-81.
[5]	SHI Zhuo-qi, LIU Li-yao, XIONG Qian, WANG Qing-kui. Formulation optimization of calycosin phospholipid complex [J]. Journal of Tianjin Agricultural University, 2019, 26(4): 77-82.
[6]	LIU Tong, WANG Xue-meng, LIU Li-yao, WANG Qing-kui. Study on ointment formulation design of extracts from Radix angelicae sinensis [J]. Journal of Tianjin Agricultural University, 2019, 26(1): 64-68.
[7]	CHEN Kun, QI Jin-yu, LIU Li-yao, WANG Qing-kui. Emulsion formulation optimization of extracts from Armeniacae Semen [J]. Journal of Tianjin Agricultural University, 2018, 25(4): 58-62.
[8]	QI Jin-yu, LI Na-kun, LIU Li-yao, WANG Qing-kui, ZHANG Yan. Ointment formulation optimization of extracts from Perilla frutescens [J]. Journal of Tianjin Agricultural University, 2018, 25(3): 65-69.
[9]	ZHANG Shi-cai, CHEN Kun, LIU Li-yao. Preparation and evaluation of self-assembled lecithin/chitosan nanoparticles for berberine hydrochloride delivery [J]. Journal of Tianjin Agricultural University, 2018, 25(1): 59-63.
[10]	WANG Hong-qian, FAN Miao-zhen, ZOU Qin, GU Wu-wei, LIU Li-yao. Study on the Ointment Preparation of Total Flavonoid Extracts from Scutellaria baicalensis Georgi [J]. Journal of Tianjin Agricultural University, 2017, 24(4): 33-37.