紫苏叶提取物乳膏剂的处方研究

doi:10.19640/j.cnki.jtau.2018.03.014

Journal of Tianjin Agricultural University ›› 2018, Vol. 25 ›› Issue (3): 65-69.doi: 10.19640/j.cnki.jtau.2018.03.014

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Ointment formulation optimization of extracts from Perilla frutescens

QI Jin-yu¹, LI Na-kun¹, LIU Li-yao^{1,2,Corresponding Author}, WANG Qing-kui², ZHANG Yan³

1. College of Basic Science, Tianjin Agricultural University, Tianjin 300384, China;
2. Tianjin Key Lab of Aquatic Ecology and Aquaculture, Tianjin Agricultural University, Tianjin 300384, China;
3. Inner Mongolia Tongliao Horqin District Agricultural Technology Extension Center, Tongliao 028000, Inner Mongolia Autonomous Region, China

Received:2018-05-15 Online:2018-09-20 Published:2019-11-12

Abstract

Abstract: Flavonoids and other effective components are abundant in extracts from leaves of Perilla frutescens with bioactivities of anti-oxidant and promoting epidermal cell growth through transdermal administration. Aiming at these characteristics, ointment was prepared for extracts from leaves of Perilla frutescens with oil-in-water（O/W）type through nascent soap method. Meanwhile, orthogonal screening was used in formulation selection in order to obtain stable ointment formulation with preferred skin-feeling. In this investigation, flavonoid ingredients were acquired through ultrasonic extraction firstly. Afterwards, comprehensive scoring of homogeneity, extensibility, centrifugal stability and cold/heat resistance was set as the evaluation indicator to obtain the optimal ratio of oil phase/water phase, triethanolamine and coemulsifier-glycerin monostearate. After prepared under the optimal formulation, in which the ratio of oil phase/water phase was 35:65, and the mass percentage of triethanolamine and glycerin monostearate was 0.6% and 3%（m/m）respectively, stable ointment was acquired in oil-in-water type. This study provided the basis for further application of Perilla frutescens extracts ointment.

Key words: Perilla frutescens extracts, orthogonal screening, ointment, formulation optimization

CLC Number:

QI Jin-yu, LI Na-kun, LIU Li-yao, WANG Qing-kui, ZHANG Yan. Ointment formulation optimization of extracts from Perilla frutescens [J]. Journal of Tianjin Agricultural University, 2018, 25(3): 65-69.

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Ointment formulation optimization of extracts from Perilla frutescens

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