慢性暴露全氟十二烷酸对雌性大鼠生殖激素及相关卵巢受体表达的影响

Journal of Tianjin Agricultural University ›› 2014, Vol. 21 ›› Issue (1): 19-22.

• Researches and Scientific Notes • Previous Articles Next Articles

Effects of Chronic Exposure of Perfluorododecanonic Acid on Reproductive Hormones and Related Ovary Receptors in Female Rats

CHEN Si-huai, LIU Jie, YANG Fan, XIAO Wu-lin, SHI Zhi-min^{Corresponding Author}

Department of Animal Medicine, Rongchang Campus of South-West University, Chongqing 402460, China

Received:2013-11-20 Published:2019-10-21

Abstract

Abstract: Perfluoroalkyl acids are a class of emerging persistent organic pollutants, the concerns on PFAAs potential risk in environment and health has been generated in environmental scientists and related agencies. In order to study the reproductive toxicology of PFAAs with long carbon chains, after 0.1 mg/kg of perfluorododecanonic acid (PFDoA) in food was used to feed female rats for 180 days, radioimmunoassay and real-time PCR were applied to detect the serum reproductive hormones and the expression of the related ovary receptors. The results show that PFDoA exhibited inhibitory trend on serum estradiol (E₂) and markedly increased serum follicle-stimulating hormone level. No change in serum luteinizing hormone was observed between control and PFDoA exposure group. Following PFDoA exposure, mRNA level of ovary E₂ receptor was dropped by 25% while ovary FSH receptor expression was increased by 36%. PFDoA exposure did not affect ovary LH receptor expression. These results suggest that chronic PFDoA exposure mainly impacts ovary E₂and FSH signal transduction.

Key words: perfluorododecanonic acid, estradiol, follicle-stimulating hormone, ovary gene expression

CLC Number:

Q786

CHEN Si-huai, LIU Jie, YANG Fan, XIAO Wu-lin, SHI Zhi-min. Effects of Chronic Exposure of Perfluorododecanonic Acid on Reproductive Hormones and Related Ovary Receptors in Female Rats[J]. Journal of Tianjin Agricultural University, 2014, 21(1): 19-22.

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Effects of Chronic Exposure of Perfluorododecanonic Acid on Reproductive Hormones and Related Ovary Receptors in Female Rats

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