新型4-氨基安替比林席夫碱的合成、表征和抑菌活性

天津农学院学报 ›› 2012, Vol. 19 ›› Issue (1): 30-33.

新型4-氨基安替比林席夫碱的合成、表征和抑菌活性

张淼, 许玮, 任俊杰, 朱华玲^通讯作者, 白亚南, 王学荣

天津农学院基础科学系,天津 300384

收稿日期:2011-12-26 出版日期:2012-03-20 发布日期:2019-11-12
通讯作者: 朱华玲（1975-）,女,山东青州人,讲师,硕士,研究方向为功能化合物的合成与活性。联系电话：（022）23784019。
作者简介:张淼（1989-）,女,天津市人,本科在读,主要从事应用化学（生物制药）方面的研究。联系电话：（022）23784019。
基金资助:
天津农学院大学生科研创新项目“新型β-二酮类席夫碱金属配合物的合成与生物活性研究”（无编号）

Synthesis, Characterization and Antibacterial Study of Some New 4-Amino Antipyrine Schiff Bases

ZHANG Miao, Xv Wei, REN Jun-jie, ZHU Hua-ling^{Corresponding Author}, BAI Ya-nan, WANG Xue-rong

Department of Basic Courses, Tianjin Agricultural University, Tianjin 300384, China

Received:2011-12-26 Online:2012-03-20 Published:2019-11-12

摘要/Abstract

摘要： 合成了3种新型芳基吡唑酮（1-苯基-3-甲基- 4-乙酰基-5-吡唑啉酮、1-苯基-3-甲基-4-甲酰-5-Cl-吡唑和苯甲酰丙酮）缩4-氨基安替比林席夫碱,对合成的化合物进行了元素分析、光谱分析（红外和紫外）以及HNMR分析。采用纸片扩散法,测试了化合物对大肠杆菌和枯草芽孢杆菌的抗菌活性。结果表明,所有化合物都有一定的抑制大肠杆菌和枯草芽孢杆菌生长的活性。

关键词: 安替比林, 席夫碱, 合成表征, 抑菌活性

Abstract: Three new Schiff bases derived from L₁ （where L₁=1-phenyl-3-methyl-4-acetyl- 5-pyrazolone, 1-phenyl-3-methyl-4-formyl-5-Cl-pyrazole and benzoylacetone） and 4- Amino antipyrine have been prepared and characterized by elemental analysis, spectroscopic data （IR and UV） and HNMR. The antibacterial activity tests of the compounds at different concentrations against Bacillus coli and Bacillus subtilis were performed by using disc diffusion method. The results indicate that almost all compounds have the activity of inhibiting the growth of the two bacteria.

Key words: antipyrine, schiff bases, synthesis and characterization, antibacterial study

中图分类号:

O621.147

张淼, 许玮, 任俊杰, 朱华玲, 白亚南, 王学荣. 新型4-氨基安替比林席夫碱的合成、表征和抑菌活性[J]. 天津农学院学报, 2012, 19(1): 30-33.

ZHANG Miao, Xv Wei, REN Jun-jie, ZHU Hua-ling, BAI Ya-nan, WANG Xue-rong. Synthesis, Characterization and Antibacterial Study of Some New 4-Amino Antipyrine Schiff Bases[J]. Journal of Tianjin Agricultural University, 2012, 19(1): 30-33.

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http://xuebao.tjau.edu.cn/CN/Y2012/V19/I1/30

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