Abstract: The core-shell metal-organic framework was synthesized by one-pot reaction with Zn metal salts, or Co metal salts, 2-methylimidazole ligands and Carboxylated magnetic nanoparticles in this research. BSA was encapsulated by MOF materials self-assembled and released in PBS buffer. The ability of the sample to release BSA was determined by fluorescence spectrophotometry, and the potential of imidazole based core-shell magnetic metal-organic framework materials in vaccine carriers was explored. By a variety of representational means, the synthesis of γ-Fe₂O₃@SiO₂-NH₂-COOH/ZIF-8 and γ-Fe₂O₃@SiO₂-NH₂-COOH/ZIF-67 were confirmed by infrared spectroscopy（IR）and X-ray diffraction（XRD）. The XRD measurements of used materials confirmed the materials used as vaccine vectors suffered structural collapse after the BSA released. The residue characteristic diffraction peaks indicated that the prepared γ-Fe₂O₃@SiO₂-NH₂-COOH/ZIF-8 and γ-Fe₂O₃@SiO₂-NH₂-COOH/ZIF-67 as vaccine vector would be disintegrated after release in vitro. Therefore, the prepared γ-Fe₂O₃@SiO₂-NH₂-COOH/ZIF-8 and γ-Fe₂O₃@SiO₂-NH₂-COOH/ZIF-67 can provide a reference for the development of new vaccine vectors.

Key words: magnetic nanoparticles, magnetic metal-organic framework, BSA, vaccine vectors