新城疫病毒HN蛋白的抑瘤机制及其研究进展

Journal of Tianjin Agricultural University ›› 2014, Vol. 21 ›› Issue (3): 49-52.

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Antitumor Mechanism of Newcastle Disease Virus HN Protein and Its Research Progress

GAO Jing^1,2, DONG Dong-xiao¹, LONG Yu-qing¹, LI Meng¹, LI Liu-an¹, JIN Tian-ming^{1,Corresponding Author}

1. College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China;
2. Tianjin Shengji Group Limited Company, Tianjin 300384, China

Received:2013-10-18 Online:2014-09-20 Published:2019-10-21

Abstract

Abstract: The large spike-like membrane glycoproteins from the Newcastle disease virus envelope were encoded by Newcastle disease virus hemagglutinin-neuraminidase（HN）gene. HN protein is the abbreviated form of hemagglutinin-neuraminidase protein, it not only mediates virus adsorption on tumor cells, but also makes virus invade tumor cells with the help of the fusion protein, and its neuraminidase activity can hydrolyze surface sialic acid of the host cells and expose the biological recognition sites of host cells. It is also able to hydrolyze sialic acid lying on sugar chain end of virus particle surface, prevent virus particles from clustering on the host surface, furthermore, it can introduce new immunogenic factors and adhesion molecules to induce the recognition of immune systems.

Key words: Newcastle disease virus, HN protein, antitumor mechanism

CLC Number:

S857.4

GAO Jing, DONG Dong-xiao, LONG Yu-qing, LI Meng, LI Liu-an, JIN Tian-ming. Antitumor Mechanism of Newcastle Disease Virus HN Protein and Its Research Progress[J]. Journal of Tianjin Agricultural University, 2014, 21(3): 49-52.

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Antitumor Mechanism of Newcastle Disease Virus HN Protein and Its Research Progress

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