新城疫病毒HN蛋白的抑瘤机制及其研究进展

天津农学院学报 ›› 2014, Vol. 21 ›› Issue (3): 49-52.

新城疫病毒HN蛋白的抑瘤机制及其研究进展

高静^1,2, 董东晓¹, 龙雨清¹, 李萌¹, 李留安¹, 金天明^{1,通信作者}

1. 天津农学院动物科学与动物医学学院,天津 300384;
2. 天津生机集团股份有限公司,天津 300384

收稿日期:2013-10-18 出版日期:2014-09-20 发布日期:2019-10-21
通讯作者: 金天明（1968-）,男,内蒙古通辽人,教授,博士,主要研究方向为分子免疫病理学。E-mail：jtm680@163.com。
作者简介:高静（1982-）,女,天津市人,工程师,硕士,研究方向为中兽药新药研发及兽医生物技术与疫苗。E-mail：gj090329@163.com。
基金资助:
国家自然基金项目“TRAIL和HN基因重组腺病毒的构建及其对禽白血病肿瘤细胞的抑制作用”（31072109）; 天津市高等学校科技发展基金项目“APP菌影载体猪巴氏杆菌基因疫苗的研究”（20060720）; 天津市自然科学基金重点项目“Ad-TRAIL- 2A-HN的构建及其对MD肿瘤细胞的抑制作用”（12JCZDJC22100）

Antitumor Mechanism of Newcastle Disease Virus HN Protein and Its Research Progress

GAO Jing^1,2, DONG Dong-xiao¹, LONG Yu-qing¹, LI Meng¹, LI Liu-an¹, JIN Tian-ming^{1,Corresponding Author}

1. College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China;
2. Tianjin Shengji Group Limited Company, Tianjin 300384, China

Received:2013-10-18 Online:2014-09-20 Published:2019-10-21

摘要/Abstract

摘要： 新城疫病毒囊膜上较大的纤突样糖蛋白由新城疫病毒血凝素-神经氨酸酶（HN）基因编码。HN蛋白即血凝素-神经氨酸酶蛋白,它不仅介导病毒吸附于肿瘤细胞,而且与融合蛋白一起帮助病毒侵入肿瘤细胞,其神经氨酸酶活性能水解宿主细胞表面的唾液酸,暴露宿主细胞的生物识别位点。它还能够水解病毒粒子表面糖链末端的唾液酸,防止病毒粒子在宿主表面簇集,并且能够引入新的粘附因子和免疫原性分子,诱导机体免疫系统识别。

关键词: 新城疫病毒, HN蛋白, 抑瘤机制

Abstract: The large spike-like membrane glycoproteins from the Newcastle disease virus envelope were encoded by Newcastle disease virus hemagglutinin-neuraminidase（HN）gene. HN protein is the abbreviated form of hemagglutinin-neuraminidase protein, it not only mediates virus adsorption on tumor cells, but also makes virus invade tumor cells with the help of the fusion protein, and its neuraminidase activity can hydrolyze surface sialic acid of the host cells and expose the biological recognition sites of host cells. It is also able to hydrolyze sialic acid lying on sugar chain end of virus particle surface, prevent virus particles from clustering on the host surface, furthermore, it can introduce new immunogenic factors and adhesion molecules to induce the recognition of immune systems.

Key words: Newcastle disease virus, HN protein, antitumor mechanism

中图分类号:

S857.4

高静, 董东晓, 龙雨清, 李萌, 李留安, 金天明. 新城疫病毒HN蛋白的抑瘤机制及其研究进展[J]. 天津农学院学报, 2014, 21(3): 49-52.

GAO Jing, DONG Dong-xiao, LONG Yu-qing, LI Meng, LI Liu-an, JIN Tian-ming. Antitumor Mechanism of Newcastle Disease Virus HN Protein and Its Research Progress[J]. Journal of Tianjin Agricultural University, 2014, 21(3): 49-52.

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