4-酰基吡唑啉酮-5缩γ-氨基丁酸衍生物的合成及对白玉菇菌丝脱氢酶活性影响

doi:10.19640/j.cnki.jtau.2022.02.001

Journal of Tianjin Agricultural University ›› 2022, Vol. 29 ›› Issue (2): 1-6.doi: 10.19640/j.cnki.jtau.2022.02.001

• Researches and Scientific Notes • Next Articles

Synthesis of the derivatives from 4-acylpyrazolone-5 and γ-aminobutyric acid and their effects on the dehydrogenase activity of Hypsizygus marmoreus mycelia

Wang Xin^a, Shi Xinyimei^a, Xie Fenlan^a, Fu Zhuang^a, Zhu Hualing^{a,Corresponding Author}, Ban Litong^b

Tianjin Agricultural University, a. College of Basic Sciences, b. College of Agronomy and Resource Environment, Tianjin 300392, China

Received:2020-10-30 Online:2022-06-30 Published:2022-07-05

Abstract

Abstract: A new ligand（L1）derived from γ-aminobutyric acid and 4-trifluoroacetyl-3- methyl-1-phenyl-5-pyrazolone, and a new ligand（L2）derived from γ-aminobutyric acid and 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone were synthesized and characterized by IR and UV, so did their Ca, Zn complexes. The inhibititted effect of the compounds on the mycelium dehydrogenase activity of Hypsizygus marmoreus was determined by MTT methods. The results showed that ligand L2 had stronger inhibitition ability to mycelium dehydrogenase while ligand L1 was the weaker. Molecular docking method was used to analysize the interaction of the mycelium dehydrogenase and the ligands. The results suggested that the two new ligands showed higher interactions to mycelium dehydrogenase than original ubiquinone, and ligand L2 showed higher interactions to mycelium dehydrogenase than ligand L1.

Key words: γ-aminobutyric acid, derivatives, synthesis, scharacterization, Hypsizigus marmoreus, dehydrogenase activity

CLC Number:

O621.1

Wang Xin, Shi Xinyimei, Xie Fenlan, Fu Zhuang, Zhu Hualing, Ban Litong. Synthesis of the derivatives from 4-acylpyrazolone-5 and γ-aminobutyric acid and their effects on the dehydrogenase activity of Hypsizygus marmoreus mycelia[J]. Journal of Tianjin Agricultural University, 2022, 29(2): 1-6.

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Synthesis of the derivatives from 4-acylpyrazolone-5 and γ-aminobutyric acid and their effects on the dehydrogenase activity of Hypsizygus marmoreus mycelia

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