猪链球菌黏附机制及其相关毒力因子研究进展

Journal of Tianjin Agricultural University ›› 2017, Vol. 24 ›› Issue (4): 77-80.

• Reviews • Previous Articles Next Articles

Research Advances of Adhesion Mechanism and Pathogenic Factor in Streptococcus suis

FU Chao, LIU Meng-yue, ZHAO Rui-li^{Corresponding Author}, HU Ye, MA Ji-fei, CUI Jun

College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China

Received:2017-08-15 Online:2017-12-31 Published:2019-10-15

Abstract

Abstract: Streptococcus suis（S. suis）is a momentous zoonotic pathogen, with wide range of epidemic and strong ability of pathogenic, which could cause a series of swine disease as well as pose a serious threat to human health. In recent years, some reports about S. suis infected people and animals are increasing, and it attracted people’s widespread attention gradually. The first step of the pathogenesis of S. suis infection is the adhesion to host, the studies onthe adhesion and virulence factors （such asplcR, etc.）of the bacterium have become a research hotspot. In the review, the adhesion and virulence factors of S. suis were mainly overviewed, meanwhile, the main adherentmechanism and involved virulence factors were summarized, the aim of it is to lay a foundation for the further study of S. suis, and to provide a reference for prevention and control of S. suis infection.

Key words: S. suis, adhesion mechanism, virulence factor

CLC Number:

S852.611

FU Chao, LIU Meng-yue, ZHAO Rui-li, HU Ye, MA Ji-fei, CUI Jun. Research Advances of Adhesion Mechanism and Pathogenic Factor in Streptococcus suis[J]. Journal of Tianjin Agricultural University, 2017, 24(4): 77-80.

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: http://xuebao.tjau.edu.cn/EN/

http://xuebao.tjau.edu.cn/EN/Y2017/V24/I4/77

References

[1] Segura M.Streptococcus suis:an emerging human threat[J].The Journal of Infectious Diseases,2008,199(1):4-6.
[2] Sánchez D R V,Fernández-Garayzábal J F,Domínguez L,et al. Screening of virulence-associated genes as a molecular typing method for characterization of Streptococcus suis isolates recovered from wild boars and pigs[J]. Veterinary Journal,2015,209(3):108-112.
[3] Lun Z R,Wang Q P,Chen X G,et al.Streptococcus suis:an emerging zoonotic pathogen[J].The Lancet Infectious Diseases,2007,7(3):201-206.
[4] 黎敏. 2型猪链球菌分离鉴定及毒力基因检测[J]. 广东畜牧兽医科技,2016,41(3):18-20.
[5] 周康,李宗明,李江华,等. 猪链球菌Ⅱ型五种感染途径感染猪模型的比较[J]. 中国动物传染病学报,2016,24(2):35-41.
[6] Marie-Claude J,Daniel G.Identification and characterization of four proteases produced by Streptococcus suis[J]. FEMS Microbiology Letters,2003,220(1):113-119.
[7] Segura M,Calzas C,Grenier D,et al.Initial steps of the pathogenesis of the infection caused by Streptococcus suis:fighting against nonspecific defenses[J]. FEBS Letters,2016,590(21):3772-3799.
[8] 刘耀川,宋淑英,张泽辉,等. 猪链球菌毒力因子简介[J]. 湖北畜牧兽医,2015,36(3):7-8.
[9] 曾巧英,陆承平. 猪链球菌2型溶菌酶释放蛋白诱导上皮细胞融合和凋亡[J]. 微生物学报,2003(3):407-412.
[10] 陈瑶,张雅为,王宏燕,等. 猪链球菌2型研究进展[J].现代畜牧兽医,2010(7):72-74.
[11] 黎敏. 2型猪链球菌分离鉴定及毒力基因检测[J]. 广东畜牧兽医科技,2016,41(3):18-20.
[12] 曾巧英,陆承平. 猪链球菌2型溶菌酶释放蛋白的黏附作用[J]. 南京农业大学学报,2002,25(4):67-71.
[13] Vecht U,Wisselink H J,Jellema M L,et al.Identification of two proteins associated with virulence of Streptococcus suis type 2[J]. Infection and Immunity,1991,59(9):3156-3162.
[14] Wisselink H J,Vecht U,Stockhofe-Zurwieden N,et al.Protection of pigs against challenge with virulent Streptococcus suis serotype 2 strains by a muramidase-released protein and extracellular factor vaccine[J]. Veterinary Record,2001,148(15):473-477.
[15] Pian Y Y,Li X Q,Zheng Y L,et al.Binding of Human Fibrinogen to MRP Enhances Streptococcus suis Survival in Host Blood in a α_Xβ₂Integrin-dependent Manner[J]. Scientific Reports of Nature,2016,6(26966):1-12.
[16] 吴萍萍. 猪链球菌2型毒力因子及疫苗候选蛋白研究进展[J]. 畜牧与饲料科学,2013(11):123-127.
[17] 高尚庆,雷连成,韩文瑜. 猪链球菌2型主要毒力因子研究进展[J]. 中国生物制品学杂志,2006,19(6):657-659.
[18] Chen S L,Xie W L,Wu K,et al.Suilysin Stimulates the Release of Heparin Binding Protein from Neutrophils and Increases Vascular Permeability in Mice[J]. Front in Microbiology,2016,7(1338):1-12.
[19] Musyoki A M,Shi Z Y,Xuan C L,et al.Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram-positive bacterium Streptococcus suis[J]. PNAS of USA,2016,113(48):13869-13874.
[20] Hoffmann C,Ohlsen K,Hauck C R.Integrin-mediated uptake of fibronectin-binding bacteria[J]. European Journal of Cell Biology,2011,90(11):891-896.
[21] 吴立志,王金良,肖跃强,等. 猪链球菌2型毒力因子研究进展[J]. 动物医学进展,2012,33(6):118-122.
[22] Fittipaldi N,Segura M,Grenier D,et al.Virulence factors involved in the pathogenesis of the infection caused by the swine pathogen and zoonotic agent Streptococcus suis[J].Future Microbiology,2012,7(2):259-279.
[23] 杨宝玲,陈福广,谢芳,等. 2型猪链球菌SsU05-0474的表达纯化及单克隆抗体制备[J]. 中国动物传染病学报,2016,24(2):25-30.
[24] Zheng C K,Xu J L,Shi G L,et al.Formate- tetrahydrofolate ligase is involved in the virulence of Streptococcus suis serotype2[J]. Microbial Pathogenesis,2016,98(9):149-154.
[25] 鞠爱萍,王长军,李明,等. 猪链球菌2型反应调控因子RevS突变株的构建[J]. 中华流行病学杂志,2008,29(1):59-64.
[26] Greeff A d,Buys H,Alphen L V,et al. Response regulator important in pathogenesis of Streptococcus suis serotype 2[J]. Microbial Pathogenesis,2002,33(4):185-192.
[27] 王玲,陈亚华,Mahillon J,等. 蜡状芽胞杆菌转录激活子pIcR调控多基因的表达[J]. 微生物学报,2001,41(3):304-309.
[28] 陈恬. SezAT系统及PlcR转录调控因子在2型猪链球菌中的作用研究[D]. 重庆:第三军医大学,2014.
[29] 浦坚华,毛紫微,王琼,等. 猪链球菌病的研究进展[J]. 上海畜牧兽医通讯,2016(4):13-15.
[30] 张维谊,王晓旭,宁昆,等. 猪源猪链球菌耐药情况分析[J]. 中国农业信息,2016(11):101-103.

Research Advances of Adhesion Mechanism and Pathogenic Factor in Streptococcus suis

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 1

Recommended Articles

Metrics

Comments