新型4-氨基安替比林席夫碱的合成、表征和抑菌活性

Journal of Tianjin Agricultural University ›› 2012, Vol. 19 ›› Issue (1): 30-33.

• Researches and Scientific Notes • Previous Articles Next Articles

Synthesis, Characterization and Antibacterial Study of Some New 4-Amino Antipyrine Schiff Bases

ZHANG Miao, Xv Wei, REN Jun-jie, ZHU Hua-ling^{Corresponding Author}, BAI Ya-nan, WANG Xue-rong

Department of Basic Courses, Tianjin Agricultural University, Tianjin 300384, China

Received:2011-12-26 Online:2012-03-20 Published:2019-11-12

Abstract

Abstract: Three new Schiff bases derived from L₁ （where L₁=1-phenyl-3-methyl-4-acetyl- 5-pyrazolone, 1-phenyl-3-methyl-4-formyl-5-Cl-pyrazole and benzoylacetone） and 4- Amino antipyrine have been prepared and characterized by elemental analysis, spectroscopic data （IR and UV） and HNMR. The antibacterial activity tests of the compounds at different concentrations against Bacillus coli and Bacillus subtilis were performed by using disc diffusion method. The results indicate that almost all compounds have the activity of inhibiting the growth of the two bacteria.

Key words: antipyrine, schiff bases, synthesis and characterization, antibacterial study

CLC Number:

O621.147

ZHANG Miao, Xv Wei, REN Jun-jie, ZHU Hua-ling, BAI Ya-nan, WANG Xue-rong. Synthesis, Characterization and Antibacterial Study of Some New 4-Amino Antipyrine Schiff Bases[J]. Journal of Tianjin Agricultural University, 2012, 19(1): 30-33.

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Synthesis, Characterization and Antibacterial Study of Some New 4-Amino Antipyrine Schiff Bases

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