PEG修饰Fe3O4纳米粒子（MNPs）的制备及载药研究

doi:10.19640/j.cnki.jtau.2020.03.010

Journal of Tianjin Agricultural University ›› 2020, Vol. 27 ›› Issue (3): 43-48.doi: 10.19640/j.cnki.jtau.2020.03.010

• Researches and Scientific Notes • Previous Articles Next Articles

Preparation and drug loading of PEG modified Fe₃O₄ nanoparticles

XIN Liang-liang¹, SHU Yue², LIU Huan¹, HU Ya-wen², YANG Lin-yan^{2,Corresponding Author}

1. Domestic Discovery Service Unit, Wuxi App Tec Co., Ltd., Tianjin 300457, China;
2. Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China

Received:2019-07-03 Online:2020-10-10 Published:2020-10-10

Abstract

Abstract: Doxorubicin hydrochloride（DOX）is an anti-tumor antibiotic that acts by inhibiting the synthesis of nucleic acid in cancer cells. DOX has a broad anti-tumor spectrum and has a killing effect on a variety of tumor cells. In this paper, Fe₃O₄ nanoparticles（MNPs）were prepared by co-precipitation synthesis method, while Fe₃O₄@SiO₂ and Fe₃O₄@SiO₂–NH₂ nanoparticles were prepared by optimizing experimental conditions. And then single and double carboxyl PEG were applied to modify Fe₃O₄@SiO₂–NH₂ samples. Fe₃O₄@SiO₂–NH₂–PEG and Fe₃O₄@SiO₂–NH₂–PEG–COOH samples could be obtained. PEG modified products were loaded with different quality of DOX. Fe₃O₄@SiO₂–NH₂–PEG·DOX and Fe₃O₄@SiO₂– NH₂–PEG–COOH·DOX samples could be obtained. After detection by a fluorescence spectrophotometer, a conclusion was drawn. The results showed that PEG–modified Fe₃O₄ nanoparticles（MNPs）loaded with different masses of DOX could increase the magnetic targeting properties of DOX, at the same time, biocompatibility could also be enhanced via the introduction of PEG.

Key words: Fe₃O₄, PEG modification, DOX, drug-loading

CLC Number:

O656.22

XIN Liang-liang, SHU Yue, LIU Huan, HU Ya-wen, YANG Lin-yan. Preparation and drug loading of PEG modified Fe₃O₄ nanoparticles[J]. Journal of Tianjin Agricultural University, 2020, 27(3): 43-48.

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Preparation and drug loading of PEG modified Fe₃O₄ nanoparticles

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Preparation and drug loading of PEG modified Fe3O4 nanoparticles

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Preparation and drug loading of PEG modified Fe₃O₄ nanoparticles