LncRNA参与转录后调控作用机制研究进展

doi:10.19640/j.cnki.jtau.2022.02.016

天津农学院学报 ›› 2022, Vol. 29 ›› Issue (2): 85-87.doi: 10.19640/j.cnki.jtau.2022.02.016

LncRNA参与转录后调控作用机制研究进展

杨旭, 訾晶晶, 郭宏, 丁向彬, 刘新峰^通信作者, 张林林^通信作者

天津农学院动物科学与动物医学学院天津市农业动物繁育与健康养殖重点实验室,天津 300392

收稿日期:2020-05-18 出版日期:2022-06-30 发布日期:2022-07-05
通讯作者: 张林林（1988—）,女,讲师,博士,研究方向为动物分子遗传育种。E-mail：zhangll@126.com。
刘新峰（1981—）,男,副教授,博士,研究方向为动物配子与胚胎工程、畜禽健康养殖。E-mail：lxf20001924036@126.com。
作者简介:杨旭（1996—）,女,硕士在读,研究方向为动物转基因与分子育种。E-mail：17332775057@163.com。
基金资助:
天津市自然科学基金项目（18JCYBJC95800）; 天津市教委科研计划项目（2018KJ183）

Research progress on the mechanism of lncRNA involved in post-transcriptional regulation

Yang Xu, Zi Jingjing, Guo Hong, Ding Xiangbin, Liu Xinfeng^{Corresponding Author}, Zhang Linlin^{Corresponding Author}

Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China

Received:2020-05-18 Online:2022-06-30 Published:2022-07-05

摘要/Abstract

摘要： 长链非编码RNA（long non-coding RNA,lncRNA）是广泛存在于动植物细胞中的一类长度大于200 nt的非编码RNA,lncRNA能够与DNA、RNA或蛋白质相互作用调控生物体的各项生理过程。近年来,国内外大动物遗传育种领域也报道了许多新鉴定出来的lncRNAs,但畜牧领域仍缺乏相关lncRNA作用机制研究。主要从lncRNA调控mRNA的剪接、转运、翻译和降解等方面阐述了lncRNA与mRNA相互作用参与转录后调控的机制,并对lncRNA在动物遗传育种中的研究前景进行了展望,以期为深入开展lncRNA在大动物体内的功能研究提供参考。

关键词: lncRNA, mRNA, 转录后调控

Abstract: Long non-coding RNA（lncRNA）is a kind of non-coding RNA with a length longer than 200 nt which widely exists in animal and plant cells. LncRNA can interact with DNA, RNA or proteins to regulate various physiological processes of organisms. In recent years, many newly identified lncRNAs have been reported in the field of large animal genetics and breeding at home and abroad, but there is still a lack of research on the mechanism of lncRNA in the field of animal husbandry. In this article the mechanism of lncRNA-mRNA interaction in post-transcriptional regulation was mainly discussed from the aspects of splicing, transport, translation and degradation of lncRNA regulated mRNAs. The research prospects of lncRNA in animal genetics and breeding has been expected, with a view to provide reference for further development of the function research of lncRNA in large animals.

Key words: lncRNA, mRNA, post-transcriptional regulation

中图分类号:

杨旭, 訾晶晶, 郭宏, 丁向彬, 刘新峰, 张林林. LncRNA参与转录后调控作用机制研究进展[J]. 天津农学院学报, 2022, 29(2): 85-87.

Yang Xu, Zi Jingjing, Guo Hong, Ding Xiangbin, Liu Xinfeng, Zhang Linlin. Research progress on the mechanism of lncRNA involved in post-transcriptional regulation[J]. Journal of Tianjin Agricultural University, 2022, 29(2): 85-87.

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http://xuebao.tjau.edu.cn/CN/Y2022/V29/I2/85

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LncRNA参与转录后调控作用机制研究进展

Research progress on the mechanism of lncRNA involved in post-transcriptional regulation

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