病原菌感染适应宿主相关机制研究进展

doi:10.19640/j.cnki.jtau.2018.01.020

天津农学院学报 ›› 2018, Vol. 25 ›› Issue (1): 90-93.doi: 10.19640/j.cnki.jtau.2018.01.020

病原菌感染适应宿主相关机制研究进展

刘燕霏, 杨建德^通信作者

天津农学院动物科学与动物医学学院,天津 300384

收稿日期:2017-09-14 出版日期:2018-03-20 发布日期:2019-11-05
通讯作者: 杨建德（1969-）,男,教授,博士,主要从事预防兽医学方面的教学与研究。E-mail：jiandeyang@126.com。
作者简介:刘燕霏（1970-）,女,副教授,硕士,研究方向为预防兽医学。E-mail：674383573@qq.com。
基金资助:
天津市自然基金项目（07JCYBJC16000）; 天津农学院附属动物医院关键技术集成与学生综合能力提升项目（ZH004901）

Research advance on related mechanism of adaptation of bacterial infection to its host

LIU Yan-fei, YANG Jian-de^{Corresponding Author}

College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, China

Received:2017-09-14 Online:2018-03-20 Published:2019-11-05

摘要/Abstract

摘要： 病原菌造成感染,首先要克服宿主的先天性免疫和适应性免疫机制。为了适应周围环境的压力,病原菌和宿主相互作用,细菌不断发生基因和表型改变,来求得生存。本文对病原菌适应宿主机制进行阐述,包括基因改变中毒力因子下调策略,细菌表型改变,还涉及细菌的耐药性、运动性和密度感应系统等改变。

关键词: 病原菌, 适应机制, 毒力下调, 表型改变, 密度感应系统

Abstract: The pathogenic bacteria causing infection, first overcomes host innate and adaptive immunity. In order to adapt to the pressure of the surrounding environment, bacteria interact with host with genetic and phenotypic changing constantly to survive. The mechanism of adapting to host pathogen are described, including genetically altered virulence factor reduction strategy, bacterial phenotype changes such as outer membrane protein, lipopolysaccharide and exopolysaccharide, also changes of bacterial resistance, motility and the quorum sensing.

Key words: pathogenic bacteria, adaptation mechanism, virulence down regulation, phenotypic change, quorum sensing

中图分类号:

S852.61

刘燕霏, 杨建德. 病原菌感染适应宿主相关机制研究进展[J]. 天津农学院学报, 2018, 25(1): 90-93.

LIU Yan-fei, YANG Jian-de. Research advance on related mechanism of adaptation of bacterial infection to its host[J]. Journal of Tianjin Agricultural University, 2018, 25(1): 90-93.

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链接本文: http://xuebao.tjau.edu.cn/CN/10.19640/j.cnki.jtau.2018.01.020

http://xuebao.tjau.edu.cn/CN/Y2018/V25/I1/90

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病原菌感染适应宿主相关机制研究进展

Research advance on related mechanism of adaptation of bacterial infection to its host

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