NH2-MIL-68（In）的后合成修饰及其在诺氟沙星萃取中的研究

doi:10.19640/j.cnki.jtau.2025.01.007

天津农学院学报 ›› 2025, Vol. 32 ›› Issue (1): 34-38.doi: 10.19640/j.cnki.jtau.2025.01.007

NH₂-MIL-68（In）的后合成修饰及其在诺氟沙星萃取中的研究

杨琳燕, 陈峥嵘, 付雷明, 刁琦林, 张东超, 李存

天津农学院动物科学与动物医学学院天津市农业动物繁育与健康养殖重点实验室,天津 300392

收稿日期:2024-04-07 发布日期:2025-03-04
作者简介:杨琳燕（1982—）,女,讲师,博士,主要从事纳米药物载体及功能配合物研究。E-mail：y_linyan@163.com。
基金资助:
国家自然科学基金（32202760）; 农业农村部智慧养殖重点实验室（省部共建）开放课题（2023-TJAULSBF-2103）; 天津市高等院校“兽医生物技术创新团队”资助项目（TD13-5091）; 天津市大学生创新创业训练计划项目（202210061109）

Post-Synthetic modification of NH₂-MIL-68（In）and its application in the extraction of norfloxacin

Yang Linyan, Chen Zhengrong, Fu Leiming, Diao Qilin, Zhang Dongchao, Li Cun

Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China

Received:2024-04-07 Published:2025-03-04

摘要/Abstract

摘要： 金属有机框架（Metal-Organic Frameworks, MOFs）是一种由金属离子或团簇与有机连接基团通过配位键合成的多孔晶体材料。NH₂-MIL-68（In）作为一种典型的金属有机框架,因其具有高比表面积、可调孔径和功能性,在气体储存、分离、催化以及光电等领域展现出巨大的应用潜力。本研究旨在深入探讨NH₂-MIL-68（In）的结构特点、制备方法及其在相关领域的应用研究进展。通过运用多种实验手段,我们采用溶剂热法制备NH₂-MIL-68（In）,经后合成修饰分别制备出NH₂-MIL-68（In）-AA和NH₂-MIL-68（In）-CMC样品,对产物结构性质和性能表现进行了系统研究。研究发现,因NH₂-MIL-68（In）的较高比表面积和孔容,其在诺氟沙星萃取方面有很大优势,经过不同pH对诺氟沙星萃取分析,在pH=10时,NH₂-MIL-68（In）-CMC和NH₂-MIL-68（In）-AA萃取诺氟沙星的效果最好,经过不同洗脱液对诺氟沙星的萃取实验发现,NaOH的洗脱效果最好。本研究不仅加深了对NH₂-MIL-68（In）及后合成产物的结构和性能理解,也为该材料在实际生产中的进一步应用提供了实验依据。

关键词: NH₂-MIL-68（In）, 金属有机框架, 萃取, 诺氟沙星

Abstract: Metal-Organic Frameworks（MOFs）is a kind of porous crystal material synthesized by coordination bond between metal ions or clusters and organic linking groups. NH₂-MIL-68（In）, as a typical Metal-Organic Framework, shows great application potential in gas storage, separation, catalysis and optoelectronics due to its high specific surface area, adjustable pore size and functionality. The purpose of this study is to investigate the structural characteristics, synthesis methods and application of NH₂-MIL-68（In）in related fields. Through the application of various experimental methods, NH₂-MIL-68（In）was prepared by the solvothermal method, and then NH₂-MIL-68（In）-AA and NH₂-MIL-68（In）-CMC samples were prepared via the method of Post-Synthetic Modification. The structural properties and performance of the products were systematically studied. Research has found that NH₂-MIL-68（In）has significant advantages in the extraction of norfloxacin due to its high specific surface area and pore volume. After analysis of norfloxacin extraction at different pH values, NH₂-MIL-68（In）-CMC and NH₂-MIL-68（In）-AA had the best effects in norfloxacin extraction at pH=10. And NaOH was found to have the best elution effect. This study not only deepens the understanding of the structure and properties of NH₂-MIL-68（In）and its subsequent synthesized products, but also provides experimental basis for the further development of this material in practical applications.

Key words: NH₂-MIL-68（In）, MOFs, extraction, norfloxacin

中图分类号:

O658.2

杨琳燕, 陈峥嵘, 付雷明, 刁琦林, 张东超, 李存. NH₂-MIL-68（In）的后合成修饰及其在诺氟沙星萃取中的研究[J]. 天津农学院学报, 2025, 32(1): 34-38.

Yang Linyan, Chen Zhengrong, Fu Leiming, Diao Qilin, Zhang Dongchao, Li Cun. Post-Synthetic modification of NH₂-MIL-68（In）and its application in the extraction of norfloxacin[J]. Journal of Tianjin Agricultural University, 2025, 32(1): 34-38.

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http://xuebao.tjau.edu.cn/CN/Y2025/V32/I1/34

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NH₂-MIL-68（In）的后合成修饰及其在诺氟沙星萃取中的研究

Post-Synthetic modification of NH₂-MIL-68（In）and its application in the extraction of norfloxacin

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