氨基酸衍生物介入的支化聚乳酸的合成研究

天津农学院学报 ›› 2017, Vol. 24 ›› Issue (1): 62-65.

氨基酸衍生物介入的支化聚乳酸的合成研究

杨延波, 李恒, 潘虹^通信作者, 石军, 赵蔚鑫

天津农学院基础科学学院,天津 300384

收稿日期:2016-08-15 出版日期:2017-03-31 发布日期:2019-10-15
通讯作者: 潘虹（1979-）,女,河北永清人,副教授,博士,主要从事智能高分子合成及应用的研究。E-mail：panhong79@tju.edu.cn。
作者简介:杨延波（1994-）,男,河南洛阳人,本科在读,主要从事支化聚合物的合成及应用研究。E-mail：514204715@qq.com。
基金资助:
天津市应用基础及前沿技术研究计划项目“天然活性成分雏菊叶龙胆酮的晶型与活性相关研究”（15JCQNJC13400）; 天津市大学生创新创业训练计划项目“离子-温度双响应的超支化聚合物纳米传感器的制备与应用”（201510061033）和“氨基酸衍生物为支化单体的功能性支化聚乳酸的合成及性能研究”（201510061016）

Synthesis of Branched Polylactide Mediated by Aminoacid Derivative

YANG Yan-bo, LI Heng, PAN Hong^{Corresponding Author}, SHI Jun, ZHAO Wei-xin

College of Basic Science, Tianjin Agricultural University, Tianjin 300384, China

Received:2016-08-15 Online:2017-03-31 Published:2019-10-15

摘要/Abstract

摘要： 由于线型聚乳酸具有结晶度高、细胞亲和性差、加工成型困难等缺点,因此本研究以N,N-二（2-羟丙基）甘氨酸（BHPG）作为支化单体和催化剂,引发丙交酯发生开环聚合反应,制备出支化聚乳酸。通过乙二醛和二异丙醇胺之间的亲和加成反应制备BHPG,并采用FT-IR、¹H NMR表征了兼具支化单体和催化剂的BHPG;然后引发丙交酯开环聚合制备支化聚乳酸,所得聚合物用GPC进行表征;并推测了氨基酸衍生物介入的制备支化聚乳酸的反应机理。

关键词: 氨基酸衍生物, 支化聚乳酸, 反应机理, 催化剂

Abstract: Due to high crystallinity, poor cell affinity and difficult processing, the branched polylactide was successful synthesized by the Ring Opening Polymerization（ROP）of lactide initiated with N,N-Bis-（2-hydroxypropyl）glycine as branched monomer and catalysts in this paper. The nucleophilic addition reaction between oxalaldehyde and diisopropanolamine was performed to prepare BHPG characterized by FT-IR、¹H NMR. Then, the ROP reaction of lactide was initiated by BHPG to obtain the branched polylactide. The obtained polymers were characterized by GPC. Finally, the mechanism of reaction, which was being mediated with amino derivative, was clarified.

Key words: aminoacid derivative, branched polylactide, mechanism, catalyst

中图分类号:

O631.5

杨延波, 李恒, 潘虹, 石军, 赵蔚鑫. 氨基酸衍生物介入的支化聚乳酸的合成研究[J]. 天津农学院学报, 2017, 24(1): 62-65.

YANG Yan-bo, LI Heng, PAN Hong, SHI Jun, ZHAO Wei-xin. Synthesis of Branched Polylactide Mediated by Aminoacid Derivative[J]. Journal of Tianjin Agricultural University, 2017, 24(1): 62-65.

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