糖皮质激素受体在动物应激时的作用及其调控

天津农学院学报 ›› 2016, Vol. 23 ›› Issue (1): 57-61.

糖皮质激素受体在动物应激时的作用及其调控

魏师^{1, 2}

1. 广东温氏食品集团股份有限公司稔村分公司,广东新兴 527400;
2. 南京农业大学动物医学院,南京 210095

收稿日期:2015-10-28 出版日期:2016-03-20 发布日期:2019-10-14
作者简介:魏师（1980-）,男,宁夏灵武人,博士,高级畜牧师,主要从事动物营养生理方面的研究。E-mail：weishiok@126.com。
基金资助:
国家自然科学基金重点项目“家猪应对运输应激的个性特征及其生理和遗传机制研究”（30430420）

Function and Regulation of Glucocorticoid Receptor in Animal Stress

WEI Shi^{1, 2}

1. Guangdong Wens Foodstuff Group CO., LTD, Rencun Branch Company, Xinxing 527400, Guangdong Province, China;
2. College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China

Received:2015-10-28 Online:2016-03-20 Published:2019-10-14

摘要/Abstract

摘要： 应激反应是以HPA轴激活为主要特征的生理过程,是所有生物对紧张性事件的适应性反应,对生物的存活具有重要的意义。HPA轴兴奋的直接结果是糖皮质激素分泌的增加。海马、杏仁核、下丘脑都表达高丰度的糖皮质激素受体,糖皮质激素受体在调控HPA轴活性上具有至关重要的作用。MR、11βHSDs及GR的多态性对糖皮质激素受体功能的发挥有着重要的调控作用。

关键词: 应激, 下丘脑-垂体-肾上腺皮质轴, 糖皮质激素受体, 调控

Abstract: Stress reaction is an adaptive response of all living organism to stressful events, and it has important significance for their survival. The main feature of stress reaction is activation of the hypothalamus- pituitary- adrenal axis (HPA axis). Abundant glucocorticoid receptor expressed in the hippocampus, amygdala and hypothalamus. Glucocorticoid receptor plays a crucial role in regulating the HPA axis' activity. The function of GR can be regulated by MR, 11βHSDs and GR's polymorphism.

Key words: stress, hypothalamus-pituitary-adrenal axis, glucocorticoid receptor, regulation

中图分类号:

S852.21

魏师. 糖皮质激素受体在动物应激时的作用及其调控[J]. 天津农学院学报, 2016, 23(1): 57-61.

WEI Shi. Function and Regulation of Glucocorticoid Receptor in Animal Stress[J]. Journal of Tianjin Agricultural University, 2016, 23(1): 57-61.

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链接本文: http://xuebao.tjau.edu.cn/CN/

http://xuebao.tjau.edu.cn/CN/Y2016/V23/I1/57

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