Profilin1的生物学作用研究进展

doi:10.19640/j.cnki.jtau.2022.03.014

天津农学院学报 ›› 2022, Vol. 29 ›› Issue (3): 78-83.doi: 10.19640/j.cnki.jtau.2022.03.014

Profilin1的生物学作用研究进展

訾晶晶, 杨旭, 来裕婷, 李新, 丁向彬, 张林林^通信作者

天津农学院动物科学与动物医学学院天津市农业动物繁育与健康养殖重点实验室,天津 300392

收稿日期:2020-07-28 出版日期:2022-09-30 发布日期:2022-10-10
通讯作者: 张林林（1988—）,女,讲师,博士,研究领域为肉牛分子遗传育种。E-mail：zhangll20@126.com。
作者简介:訾晶晶（1997—）,女,硕士在读,研究方向为调控牛骨骼肌发育的机制。E-mail：zjj0120@126.com。
基金资助:
国家自然科学基金青年项目（31902151）

Research progress on the biological function of Profilin1

Zi Jingjing, Yang Xu, Lai Yuting, Li Xin, Ding Xiangbin, Zhang Linlin^{Corresponding Author}

Tianjin Key Laboratory of Agricultural Animal Breeding and Healthy Husbandry, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China

Received:2020-07-28 Online:2022-09-30 Published:2022-10-10

摘要/Abstract

摘要： Profilin最初发现于1976年,是最早确定的肌动蛋白（actin）结合蛋白之一,因其重要的生物学作用而被广泛研究。Profilin1因可以与肌动蛋白结合从而调控细胞骨架的聚合,成为最普遍存在的亚型。最近许多研究表明,Profilin1在癌症和人类疾病中也有重要的作用。本文介绍Profilin1的生物学作用,进一步解释其对细胞骨架的调控机制,并讨论Profilin1在癌症和人类疾病中的生理和病理作用。

关键词: Profilin1, 细胞骨架, 肌动蛋白, 癌症, 疾病

Abstract: Profilin which was first discovered in 1976 was one of the earliest actin binding proteins, and has been widely studied because of its important biological role. Profilin1 is the most ubiquitous subtype because it can bind actin to regulate the polymerization of the cytoskeleton. Many recent studies have shown that Profilin1 also plays an important role in cancer and human diseases. This review mainly introduced the biological role of Profilin1, further explained its regulatory mechanism on the cytoskeleton, and discussed on the physiological and pathological role of Profilin1 in cancer and human diseases.

Key words: Profilin1, cytoskeleton, actin, cancer, disease

中图分类号:

訾晶晶, 杨旭, 来裕婷, 李新, 丁向彬, 张林林. Profilin1的生物学作用研究进展[J]. 天津农学院学报, 2022, 29(3): 78-83.

Zi Jingjing, Yang Xu, Lai Yuting, Li Xin, Ding Xiangbin, Zhang Linlin. Research progress on the biological function of Profilin1[J]. Journal of Tianjin Agricultural University, 2022, 29(3): 78-83.

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http://xuebao.tjau.edu.cn/CN/Y2022/V29/I3/78

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Profilin1的生物学作用研究进展

Research progress on the biological function of Profilin1

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