含甘二肽甲酯结构的β-二酮衍生物的合成、除草抑菌活性及构效关系

天津农学院学报 ›› 2017, Vol. 24 ›› Issue (1): 52-57.

含甘二肽甲酯结构的β-二酮衍生物的合成、除草抑菌活性及构效关系

张莉, 刘洁, 吴倩, 贺攀华, 朱华玲^通信作者, 黄治强

天津农学院基础科学学院,天津300384

收稿日期:2016-06-27 出版日期:2017-03-31 发布日期:2019-10-15
通讯作者: 朱华玲（1975-）,女,山东青州人,副教授,硕士,主要从事功能化合物的合成与活性研究。E-mail: zhuhualing2004@126.com。
作者简介:张莉（1994-）,女,天津市人,本科在读,主要从事应用化学方面的研究。联系电话：（022）23784019。
基金资助:
天津农学院大学生创新创业训练计划项目“含手性二肽片段的芳基吡唑除草剂的合成与构效关系研究”（201610061081）; 天津自然科学基金项目“含有磷酸酯结构的苯甲酰脲类杀虫剂的合成及活性研究”（14JCQNJC06300）

Synthesis, Herbicidal and Antibacterial Activities, Quantum Chemical Calculation of New β-Diketone Derivatives Containing Glycylglycine Ester

ZHANG Li, LIU Jie, WU Qian, HE Pan-hua, ZHU Hua-ling^{Corresponding Author}, HUANG Zhi-qiang

College of Basic Science, Tianjin Agricultural University, Tianjin 300384, China

Received:2016-06-27 Online:2017-03-31 Published:2019-10-15

摘要/Abstract

摘要： 合成了两个新的含甘二肽甲酯结构的β-二酮衍生物,采用IR,UV,¹H NMR以及元素分析方法对合成的化合物进行了结构表征。采用平皿法测定了化合物的除草活性,结果表明：含噻吩环和氟原子的化合物B2在浓度为100 μg/mL时,对狗尾草的抑制率基本达到100%,甚至好于对照草甘膦;采用单片纸碟法测定了化合物的抑菌活性,结果表明含噻吩环和氟原子的化合物B2具有较好的抑菌活性。

关键词: β-二酮, 甘二肽甲酯, 合成表征, 生物活性, 量化计算

Abstract: Two new β-diketone derivatives containing glycylglycine methyl ester were synthesized and characterized by IR, UV, ¹H NMR and Elemental analysis. The results of herbicidal activity tests indicated that the inhibition rates of compound B2 at 100 μg/mL to green-bristlegrass were nearly 100%, even higher than the contrast（Glyphosate）. The results of antibacterial activity tests indicated that compound B2 had higher antibacterial ability than compound B1. Theoretical study showed that the existing of thiophen ring and fluorine atoms in compound B2 was the important reason for its better biological activity.

Key words: β-diketone, glycylglycine methyl ester, synthesis, herbicidal and antibacterial activities, quantum chemical calculation

中图分类号:

TQ215

张莉, 刘洁, 吴倩, 贺攀华, 朱华玲, 黄治强. 含甘二肽甲酯结构的β-二酮衍生物的合成、除草抑菌活性及构效关系[J]. 天津农学院学报, 2017, 24(1): 52-57.

ZHANG Li, LIU Jie, WU Qian, HE Pan-hua, ZHU Hua-ling, HUANG Zhi-qiang. Synthesis, Herbicidal and Antibacterial Activities, Quantum Chemical Calculation of New β-Diketone Derivatives Containing Glycylglycine Ester[J]. Journal of Tianjin Agricultural University, 2017, 24(1): 52-57.

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http://xuebao.tjau.edu.cn/CN/Y2017/V24/I1/52

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