Abstract: Taking optical isomerism as an example, BOPPPS teaching model, which contains Bridge-in, Objective, Pre- assessment, Participatiory Learning, Post-assessment and Summary, is adopted to design in this article. With Chaoxing Xuexitong App, blended teaching is carried out by pre-class, in-class, and after-class. Before class, the lecture is introduced by life phenomena and Thalidomide tragedy. The teacher uses the interactive question-chain teaching according to the pre-assessment, intersperses scientists' stories and agricultural applications. Students participate in class deeply with short plays and group discussions, consolidate and summarize what they have learned with post-test and mind mapping after class. The practice shows that the teaching mode motivates students' learning enthusiasm, and achieves the education effect, which provides ideas for the teaching reform of Organic Chemistry.

Key words: BOPPPS, blended teaching, optical isomerism, organic chemistry